2025 TMJC H2Bio PE P3 (QP)

CANDIDATE NAME ( ) CIVICS GROUP H2 BIOLOGY 9744/03 Paper 3 Long Structured and Free-response Questions 22 September 2025 2 hours Candidates answer on the Question Paper. No additional materials are required. READ THESE INSTRUCTIONS FIRST Write your name and Civics Group in the spaces at the top of the page. Write in dark blue or black pen. You may use an HB pencil for any diagrams or graphs. Do not use staples, paper clips, glue or correction fluid. Section A Answer ALL questions. Section B Answer ONE question. The use of an approved scientific calculator is expected, where appropriate You may lose marks if you do not show your working or if you do not use appropriate units. The number of marks is given in brackets [ ] at the end of each question or part question. _________________________________________________________________________ This document consists of 27 printed pages and 3 blank pages. OVERALL Paper Score Weighting % 1 /30 15% % 2 /100 30% % 3 /75 35% % 4 /55 20% % TOTAL % GRADE For examiner’s Use Section A 1 / 28 2 / 12 3 / 10 Section B 4 or 5 / 25 Total / 75 TAMPINES MERIDIAN JUNIOR COLLEGE JC2 PRELIMINARY EXAMINATION

2 Tampines Meridian Junior College 2025 JC2 Preliminary Examinations H2 Biology Section A Answer all questions in this section. 1 Adult stem cells are undifferentiated cells that are found in most animal tissues. Adult stem cells can divide throughout their lifespan to form identical stem cells (self-renewal) or to form cells that can differentiate into the functioning cells of that tissue. (a) Uncontrolled cell division is a characteristic feature of tumour formation from a differentiated cell. (i) Describe two other features of tumour formation from a fully differentiated cell. [2] ………………………………………………………………………………………………. ………………………………………………………………………………………………. ………………………………………………………………………………………………. ………………………………………………………………………………………………. ………………………………………………………………………………………………. Telomeres are non-coding DNA found at the end of the chromosomes. Adult stem cells have chromosomes with long telomeres. (ii) Explain why having long telomeres is an advantage to cells that are undergoing many rounds of cell cycles. [2] ………………………………………………………………………………………………. ………………………………………………………………………………………………. ………………………………………………………………………………………………. ………………………………………………………………………………………………. ……………………………………………………………………………………………….

3 Tampines Meridian Junior College 2025 JC2 Preliminary Examinations H2 Biology (b) Haematopoietic stem cells (HSCs), also called blood stem cells, are adult stem cells that are located in the bone marrow. HSCs have a role in the formation of blood cells. Fig. 1.1 is an outline showing the formation of some of the