2018 Stem-Cells MCQ QP+MS

2018 Stem Cells MCQ 2018 / H2 / ACJC PRELIM / P1 Q71Which statements regarding stem cells are true? 1Researchers can induce embryonic stem cells to differentiate into various cells and tissue types to repair damaged tissue. 2The use of embryonic stem cells for research can be an ethical challenge as the continued destruction of embryos could desensitise medical communities to the destruction of life.3One of the normal functions of blood stem cells in a living organism is the transplantation of such stem cells from normal healthy bone marrow donors to leukemia patients for treatment.4Blood stem cells can potentially differentiate into neurones under appropriate chemical signals.A1, 2 and 3B1, 2 and 4 C1 and 3D2 and 4

2018 / H2 / DHS PRELIM / P1 Q92Which of the following features of the embryonic stem cells and specialized cells shown in the diagram are TRUE? Embryonic stem cellsSpecialized cellsAEmbryonic stem cells display greater plasticity when grown in culture than when in blastocyst.The blood cells are genetically different from the embryonic stem cells but have shorter telomeres.BEmbryonic stem cells are totipotent and are capable of differentiating into many different cell types.The pancreatic cells are genetically identical to the embryonic stem cells but with a different set of genes expressed. CEmbryonic stem cells are multipotent and are capable of differentiating into limited range of cell types.The blood cells are genetically different from the embryonic stem cells because different genes are expressed. DEmbryonic stem cells are pluripotent The pancreatic cells are genetically

and are capable of differentiating into many different cells types.identical to the embryonic stem cells but have shorter telomeres.

2018 / H2 / EJC PRELIM / P1 Q223Healthy, embryonic stem cells offer great promise to the cure of many diseases because ______________________.IThey are totipotent. IIThey are more readily available than other cells.IIIThey can be easily cultured in vitro.IVThey will differentiate in the presence of appropriate molecular signals and produce cells which are normal.Which of the above statement(s) is/are true?AII, III and IVBI, III and IVCI and IVDIV only2018 / H2 / JJC PRELIM / P1 Q94Stem cells are found in many tissues that require frequent cell replacement such as the skin, the intestine or the blood. However, within their own environments, a bone marrow cell cannot be induced to produce a skin cell and a skin cell cannot be induced to produce a bone marrow cell. Which statement explains this? ADifferent stem cells have only the genes required for their particular cell line. BGenes not required for a particular cell line are methylated. CGenes not required for a particular cell line are removed using restriction enzymes. DmRNA that is not required for a particular cell line is destroyed. 2018 / H2 / MJC PRELIM / P1 Q18QUESTION 5Which of the following statement(s) is/are true regarding hematopoietic stem cells and cancer cells?1Both are able to move from one location to another.2Both are found in cancer patients.3Both are specialised cells and capable to differentiate further.4Both are capable of indefinite replication.A 2 only B 1 and 3 C 2 and 4 D 1, 2 and 4

2018 / H2 / NJC PRELIM / P1 Q156Which statements are true about all stem cells?1Stem cells can be induced to differentiate by environmental signals.2Stem cells are easily isolated and propagated.3Stem cells are able to develop into whole organisms if implanted into the womb.4Stem cells make more stem cells under appropriate conditions.A1 and 4B2 and 3C1, 3 and 4D1, 2, 3 and 42018 / H2 / NYJC PRELIM / P1 Q277What is the role of stem cells with regards to the function of adult tissues and organs?AStem cells are fully differentiated cells that reside under the surface of epithelial tissue, in position to take over the function of the tissue when the overlying cells become damaged or worn out.BStem cells are totipotent cells that divide asymmetrically, giving rise to one daughter cell that remains a stem cell and one daughter cell that will differentiate to replace damaged and worn out cells in the adult tissue or organ.CStem cells are embryonic cells that persist in the adult, and can give rise to all of the cell types in the body.DStem cells are cells that have yet to express the genes and produce proteins characteristic of their differentiated state, but do so when needed for repair of tissues and organs.2018 / H2 / NYJC PRELIM / P1 Q288Stem cells are found in many tissues that require frequent cell replacement, such as the skin and the blood.A bone marrow stem cell that is transferred to the skin is never induced to produce a skin cell, and a skin stem cell that is transferred to the bone marrow is never induced to produce a blood cell.Which statement explains this?

ABinding of repressor molecules prevents the expression of genes not required for a particular cell line.BDifferent stem cells have only the genes required for their particular cell line.CExpression of genes not required for a particular cell line is controlled at translational level.DGenes not required for the differentiation of a particular cell line are methylated.2018 / H2 / RI PRELIM / P1 Q219Totipotency is demonstrated when __________.Acancer cells give rise to heterogeneous cell typesBa stem cell can differentiate into placental cells and all cells in an organismCa hematopoietic stem cell differentiates into a lymphocyteDan embryonic stem cell divides and differentiates2018 / H2 / RVHS PRELIM / P1 Q710Blood transfusion laboratories around the world are hoping to produce large numbers of red blood cells (RBCs) from ‘spare’ human embryos produced during in vitro fertilisation procedures.Embryonic stem cells are removed from an embryo and cultured in a growth medium that stimulates their differentiation into RBCs.Which statement correctly describes this differentiation?AMultipotent embryonic stem cells differentiate into pluripotent blood stem cells and then into RBCs.BPluripotent embryonic stem cells differentiate into multipotent blood stem cells and then into RBCs.CTotipotent embryonic stem cells differentiate into multipotent blood stem cells and then into RBCs.DTotipotent embryonic stem cells differentiate into pluripotent blood stem cells and then into RBCs.2018 / H2 / RI PRELIM / P1 Q2411Which is a correct statement about obtaining human embryonic stem cells for research?1Removal of these cells is considered to be ethically acceptable as normal development of the embryo is not inhibited.2The cells must be removed at an early stage of development from a region of the blastocyst known as the inner cell mass.3The cells must be removed immediately following the successful fertilisation of the ovum by the sperm, and after checking for normal mitotic division.

4The region of the blastocyst from where the cells are removed is an area that develops at a later stage into the placenta.A2 onlyB1 and 2C2 and 3D3 and 42018 / H2 / TJC PRELIM / P1 Q912Stem cells are found in many tissues that require frequent cell replacement such as the skin, the intestine and the blood.However, within their own environments, a blood cell cannot be induced to produce a skin cell and a skin cell cannot be induced to produce a blood cell.Which statement explains this?ADifferent stem cells have only the genes required for their particular cell line.BGenes not required for the differentiation of a particular cell line are methylated.CBinding of repressor molecules prevents the expression of genes not required for a particular cell line.DExpression of gene not required for a particular cell line is controlled at translational level.

2018 / H2 / VJC PRELIM / P1 Q513Bone marrow contains many stem cells. Some of these stem cells are responsible for the replacement of red blood cells. During the production of red blood cells, a series of changes occur to the cell structure. The figure below s