RVHS 5. Proteins - Structure & Function

River Valley High School 2025 JC1 H2 Biology Lecture Topic 5: Proteins – Structure and Function 1 River Valley High School 2025 JC1 H2 Biology Lecture Topic 5: Proteins – Structure and Function Name: ( ) Class: 25J__ Date: References Titles Authors Biology (9th edition) Campbell and Reece Biological Science 1. Organisms, Energy and Environment (3rd edition) Taylor, Green, Stout and Soper Longman A-Level Course in Biology: Core Syllabus Volume 1 Hoh Understanding Biology for Advanced Level (4th edition) Toole and Toole Biochemistry (3rd edition) Voet and Voet H2 Biology Syllabus 9477 (2025) Candidates should be able to use the knowledge gained in the following section(s) in new situations or to solve related problems. Related Topics Content Biomolecules of Life & Cellular transport The structure of carbohydrates, lipids and proteins and their roles in living organisms Mode of action of enzymes The fluid mosaic model of membrane structure The Structure of Nucleic Acids & Gene Expression Central Dogma – DNA to RNA, RNA to protein Learning Outcomes 1B. Biomolecules of life and cellular transport g. Describe the structure and properties of the following monomers: i. α-glucose and β-glucose (in carbohydrates) ii. glycerol and fatty acids (in lipids) iii. amino acids (in proteins) (chemical formulae of specific R-groups of different amino acids are not required) h. Describe the formation and breakage of the following bonds. i. glycosidic bond ii. ester bond iii. peptide bond

River Valley High School 2025 JC1 H2 Biology Lecture Topic 5: Proteins – Structure and Function 2 1C. Proteins m. Explain primary structure, secondary structure, tertiary structure and quaternary structure of proteins, and describe the types of bonds that hold the molecule in shape (hydrogen, ionic, disulfide bonds and hydrophobic interactions). n. Explain the effects of temperature and pH on protein structure. (KIV: Enzyme) o. Describe the molecular structure of the following proteins and explain how the structure of each protein relates to the function it plays: - haemoglobin (globular; transport) - collagen (fibrous; structural) (knowledge of details of the number of amino acids and types of secondary structures present is not required.) For practical, candidates should be able to: • carry out the Biuret test for protein. Lecture Outline I. Introduction II. Nature of Proteins III. Formation of Polypeptides IV. Proteins: Higher Orders of Structure A. Primary structure B. Secondary structure C. Tertiary structure D. Quaternary Structure V. Relating Structure to Function of Proteins A. Haemoglobin B. Collagen C. GPCR VI. Biuret Test for Protein Websites URL Description http://proteopedia.org 3D encyclopaedia of proteins and other molecules with a focus on structure/function. https://www.youtube.com/watch?v=O5uqdxQyJj8