RVHS 12. The Cell Cycle 9477

River Valley High School 2025 JC1 H2 Biology Lecture Topic 12: The Cell Cycle 1 River Valley High School 2025 JC1 H2 Biology Lecture Topic 12: The Cell Cycle Name: ( ) Class: 25J____ Date: References Title Author Biology (9th edition) Campbell and Reece Biological Science 2: Systems, Maintenance & Change (3rd edition) Taylor, Green and Stout AS Level Biology Bradfield, Dodds and Taylor Molecular Biology of the Cell (5th edition) Alberts, Johnson, Lewis, Raff, Roberts and Walter Websites URL Description Chromosome numbers during cell division How to distinguish chromosomes numbers throughout replication, mitosis and meiosis Mitosis Clear, colourful and narrated 2D animations on mitosis Cell cycle and cancer How dysregulation of cell cycle checkpoints can lead to cancer Meiosis Clear, colourful and narrated 2D animations on meiosis Mitosis and Meiosis - comparison A comparison between mitosis and meiosis Role of RAS protein in Cancer development How RAS protein affects cancer development Role of p53 in cancer How p53 protein affects cancer development Why is it so hard to cure cancer? The complications of cancer

River Valley High School 2025 JC1 H2 Biology Lecture Topic 12: The Cell Cycle 2 H2 Biology Syllabus 9477 (2025) Candidates should be able to use the knowledge gained in the following section(s) in new situations or to solve related problems. Related Topics Content DNA Replication DNA structure and function Inheritance The passage of information from parent to offspring Linkage and crossing-over Learning Outcomes 2E: The Cell Cycle a. Describe the events that occur during the mitotic cell cycle and the main stages of mitosis (including the behaviour of chromosomes, nuclear envelope, cell surface membrane and centrioles). b. Explain the significance of the mitotic cell cycle (including growth, repair and asexual reproduction) and the need to regulate it tightly. (Knowledge that dysregulation of checkpoints of cell division can result in uncontrolled cell division & cancer is required, but detail of the mechanism is not required). c. Identify the causative factors, including genetic, chemical carcinogens, ionising radiation and loss of immunity, which may increase the chances of cancerous growth. d. Explain how the loss of function mutation of tumour suppressor genes, including p53, and gain in function mutation of proto-oncogenes, including ras, results in uncontrolled cell division. e. Describe the development of cancer as a multi -step process that includes accumulation of mutations, angiogenesis and metastasis. f. Describe the events that occur during the meiotic cell cycle and the main stages of meiosis (including the behaviour of chromosomes, nuclear envelope, c ell surface membrane and centrioles) (names of the main stage