Tut 11 - Cancer (teacher)

St Andrew’s Junior College Molecular Biology of Cancer 2022 H1 Biology 1 Full Name: Civics group: 21S Index no.: Date: Core Idea 2: Genetics and Inheritance Molecular Biology of Cancer Tutorial 11 Question 1 2 3 4 5 Answer D D D B C 1 Which of the following contribute(s) towards cancer progression? 1 Activation of genes that causes cell death. 2 Inactivation of genes that slow down the cell cycle. 3 Activation of genes that result in growth of new blood vessels. 4 Inactivation of genes involved in cell-cell adhesion. A 2 only B 1 and 3 C 1 and 4 D 2, 3 and 4 2 Which of the following is not true about cancer cells? A Metastasis establishes new tumours distant from the site of the primary tumour. Metastasis establishes secondary tumours B Telomerase maintains the length of telomeres, allowing for continuous cell division. Enzyme lengthens telomeres, using a RNA template. NB: End -replication problem still occurs. C Angiogenesis forms new blood vessels and brings nutrients and oxygen to the tumour. Formation of new blood vessels also allows waste products to be carried away from rapidly dividing cells. D Cancer cells exhibit anchorage dependence . Cancer cells do not exhibit anchorage dependence, therefore they can dislodge from original tumor and und ergo metastasis.

St Andrew’s Junior College Molecular Biology of Cancer 2022 H1 Biology 2 3 The diagram represents stages in the development of a particular cancer in an adult person, over a period of 27 years. Which shows the processes happening between each of the stages indicated? stage 1 to stage 2 stage 3 to stage 4 stage 4 to stage 5 stage 5 to stage 6 A mutation proliferation mutation and proliferation mutation and proliferation B mutation mutation and proliferation proliferation mutation and proliferation C mutation and proliferation mutation and proliferation proliferation mutation D Mutation (appearance of mutated cells which look abnormal) Mutation (appearance of mutated cells which look abnormal) Proliferation (increase in number of abnormal cells) mutation (appearance of mutated cells which look abnormal)

St Andrew’s Junior College Molecular Biology of Cancer 2022 H1 Biology 3 4 It has been suggested that bre ast cancer cells produce high levels of hydrogen peroxide. This causes connective tissue cells near the cancer cells to digest some of their mitochondria, releasing nutrients which feed the cancer cells. Which observations made on breast cancer cells and connective tissue cells growing in tissue culture support this view? 1 Breast cancer cells grown alone produce hydrogen peroxide. Stated by the first sentence. 2 Treating breast cancer cells with hydrogen peroxide causes apoptosis. Question did not mention anything about apoptosis. 3 Connective tissue cells grown with breast cancer cells have reduced mitochond