Tut 11 - Cancer (student)(1)

St Andrew’s Junior College Molecular Biology of Cancer 2021 H1 Biology 1 Full Name: Civics group: 21S Index no.: Date: Core Idea 2: Genetics and Inheritance Molecular Biology of Cancer Tutorial 11 Question 1 2 3 4 5 6 7 8 9 10 Answer 1 Which of the following contribute(s) towards cancer progression? 1 Activation of genes that causes cell death. 2 Inactivation of genes that slow down the cell cycle. 3 Activation of genes that result in growth of new blood vessels. 4 Inactivation of genes involved in cell-cell adhesion. A 2 only B 1 and 3 C 1 and 4 D 2,3 and 4 2 Which of the following is not true about cancer cells? A Metastasis establishes new tumours distant from the site of the primary tumour. B Telomerase maintains the length of telomeres, allowing for continuous cell division. C Angiogenesis forms new blood vessels and brings nutrients and oxygen to the tumour. D Cancer cells exhibit anchorage dependence.

St Andrew’s Junior College Molecular Biology of Cancer 2021 H1 Biology 2 3 [9648/2013/1/19] The diagram represents stages in the development of a particular cancer in an adult person, over a period of 27 years. Which shows the processes happening between each of the stages indicated? stage 1 to stage 2 stage 3 to stage 4 stage 4 to stage 5 stage 5 to stage 6 A mutation proliferation mutation and proliferation mutation and proliferation B mutation mutation and proliferation proliferation mutation and proliferation C mutation and proliferation mutation and proliferation proliferation mutation D mutation mutation proliferation mutation

St Andrew’s Junior College Molecular Biology of Cancer 2021 H1 Biology 3 4 It has been suggested that It has been suggested that breast cancer cells produce high levels of hydrogen peroxide. This causes connective tissue cells near the cancer cells to digest some of their mitochondria, releasing nutrients which feed the cancer cells. Which observations made on breast cancer cells and connective tissue cells growing in tissue culture support this view? 1. Breast cancer cells grown alone produce hydrogen peroxide. 2. Treating breast cancer cells with hydrogen peroxide causes apoptosis. 3. Connective tissue cells grown with breast cancer cells have reduced mitochondrial activity. 4. Treating breast cancer cells with peroxidase increases cancer cell death. A 1, 2, 3 and 4 B 1, 3 and 4 only C 1 and 4 only D 2 and 3 only 5 Mammalian cells growing in tissue culture divide for several generations and form thin layers on solid surfaces. Growth is inhibited by cell-cell contact (contact inhibition). After the majority of cells have died, cancerous ce lls may remain as a result of changes that occurred in three stages. Immortalization → transformation → metastasis Descriptions of the cells in each of these stages are listed. 1. Cells can