Topic_E_Cell___Nuclear_Division_H2_2015

NANYANG JUNIOR COLLEGE H2 Biology Cell and Nuclear DivisionTopic E: Mitosis & Meiosis J1/20143 1 Formatted: Right: 0.01 cm TOPIC E: CELL & NUCLEAR DIVISION (MITOSIS & MEIOSIS) Learning Outcome Core Topic 1 – Cellular Functions Candidates should be able to: (l) Explain the importance of mitosis in growth, repair and asexual reproduction. (m) Explain the need for the production of genetically identical cells and fine control of replication. (n) Explain how uncontrolled cell growth can result in cancer, and identify causative factors (e.g. genetic, chemical carcinogens, radiation, loss of immunity) which can increase the chances of cancerous growth. (Knowledge that dysregulation of checkpoints of cell division can result in uncontrolled cell division and cancer is required, but detail of the mechanism is not required.) (o) Describe, with the aid of diagrams, the behaviour of chromosomes during the mitotic cell cycle and the associated behaviour of the nuclear envelope, cell membrane and centrioles. ( Names of the main stages are expected.) (p) Explain what is meant by homologous pairs of chromosomes. (q) Explain the need for reduction division (meiosis) prior to fertilisation in sexual reproduction. (p)(r) Explain how meiosis and random fertilisation can lead to variation. (s) Describe, with the aid of diagrams, the behaviour of chromosomes during meiosis, and t he associated behaviour of the nuclear envelope, cell membrane and centrioles. (N ames of the main stages are expected, but not the subdivisions of prophase.) Content Outline 1. The Role of Nucleus and Chromosomes in Cell Division (a) Chromatin Structure (b) Chromosome Structure (c) Chromosome Number (d) Homologous Chromosomes 1. 2. The Cell Cycle (a) Interphase (b) Mitosis (c) Cytokinesis (c)(d) Significance of Mitosis (e) Meiosis (d)(f) Significance of Meiosis (e)(g) Non-disjunction 3. Significance of Nuclear Division (a) Importance of mitosis (b) Importance of meiosis 4.3. The Control of Mitotic Cell Cycle Formatted: Font: Bold Formatted: English (Singapore) Formatted: Left, Indent: Left: 0 cm, Right: 0 cm, Space Before: 0 pt, After: 0 pt, Line spacing: single Formatted: Font: 10 pt Formatted: Font: 10 pt, Font color: Auto Formatted: Font: 10 pt Formatted: No bullets or numbering Formatted: Font: 10 pt, Font color: Auto Formatted: Numbered + Level: 1 + Numbering Style: a, b, c, … + Start at: 1 + Alignment: Left + Aligned at: 0.7 cm + Tab after: 1.4 cm + Indent at: 1.4 cm Formatted: Font: 10 pt

NANYANG JUNIOR COLLEGE H2 Biology Cell and Nuclear DivisionTopic E: Mitosis & Meiosis J1/20143 2 Formatted: Right: 0.01 cm (a) Genes involved in control of cell cycle (b) Onset of cancer (c) Causative factors References 1. Campbell, N. A. And Reece J.B. (201108) Biology. Chapter 12 :The Cell Cycle and Chapter 133: Meiosis and Sexual Life Cycles. 89th ed. Benjamin Cummings Publishing, Inc. 2. Clegg, C . J. And